Table of Contents

2006 Updates: Neoplasia Update 2006 Molecular Biology/Pathology

I.General Nature of Neoplasia

• Introduction

• Definitions

• Classification

II.Biological Characteristics of Benign and Malignant Neoplasms

• Introduction

• Structure of Tumors and Tumor Cells

• Growth Characteristics of Tumor Cells

• Clonal Origin and Progression of Tumors

• Precursor Lesions and Carcinoma in Situ

• Invasion and Metastasis of Malignant Tumor Cells

• Spontaneous Regression of Tumors

III.Grading and Staging of Cancers

IV.Etiology of Cancer: Carcinogenesis

• Introduction

• Oncogenic Viruses

• Oncogenes and Proto-oncogenes

• Oncogenes and Human Cancers

• Tumor Suppressor Genes

• DNA Mismatch-Repair Genes

• Apoptosis

• Human Cancer Cells Created with Defined Genetic Elements

• Cancer Susceptibility Genes

• Chemical and Physical Carcinogenesis

V.Biological Properties of Neoplastic Cells

• Introduction

• Growth Characteristics of Neoplastic Cells in Experimental Systems

• Structural Changes in Cells on Neoplastic Transformation

• Proteases

• Angiogensis

• Inappropriate Expression of Genetic Information

• Intracellular Metabolism

• Growth Control Mechanisms and their Relation to Neoplasia

VI.Tumor-Host Interrelations: Clinical Relevance

• Effects of Tumor on Host

• Effects of Host on Tumor

VII.Cancer Statistics and Predisposition to Cancer

• Cancer Incidence and Mortality

• Heredity and Cancer

VIII.Chromosomal Abnormalities in Cancer

• Telomeres

IX.Tumor Markers

X.Procedures in Tumor Diagnosis and Staging

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