Table of Contents

I. Recognition, Magnitude and Cause of AIDS Epidemic

II. Human Immunodeficiency Virus

• Classification of HIV
  
• HIV virion
  
• HIV genome
  
• Life cycle of HIV
  

III. Natural History of HIV Infection

• Acute retroviral syndrome
  
• Clinical latency
  
• Clinically apparent disease
  

IV. Pathogenesis of HIV Infection and AIDS

• Normal immunity
  
• Immune deficiency in HIV infection
  
  • CD4 T-cell depletion
    
  • Direct HIV-mediated cytopathic effects
    
  • HIV-specific immune responses
    
    • Cytotoxic CD8 T-cells
      
    • Neutralizing and enhancing antibodies
      
    • Natural killer cells
      
  • Other postulated mechanisms
    
    • Autoimmune mechanisms
      
    • Anergy
      
    • Superantigens
      
    • Programmed cell death
      
  • B-cell dysfunction
    
• HIV infection of lymphoid organs
  

V. Other and Newer Aspects of HIV Disease

• Body fluids and HIV transmission
  
• HIV infection of other cells
  
• Induction of HIV expression
  
• Heterogeneity of HIV strains
  
• Rapid Turnover of Plasma Virus and CD4 T-cells in HIV Infection
  
• Prognosis in HIV Infection Predicted by Plasma Viral Load
  
• Long-Term Nonprogressive HIV Infection
  
• Cancer Development in HIV Infection
  
• Co-receptors for HIV: Clinical Relevance
  
• New Protease Inhibitor (PI) Class of Antiretroviral Drugs
  
• Potential Vaccine Trials
  

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